Invited Article : Functional imaging in Parkinson disease
Identifieur interne : 002397 ( Main/Exploration ); précédent : 002396; suivant : 002398Invited Article : Functional imaging in Parkinson disease
Auteurs : R. Nandhagopal [Canada] ; Martin J. Mckeown [Canada] ; A. Jon Stoessl [Canada]Source :
- Neurology [ 0028-3878 ] ; 2008.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Objective: Functional imaging techniques represent useful tools to assess in vivo the neurochemical alterations and functional connectivity in Parkinson disease (PD). Here, the authors review the various approaches and potential application of these imaging techniques to the study of PD. Method: Radiotracer imaging using dopaminergic markers facilitates assessment of pre- and postsynaptic nigrostriatal integrity, while imaging with other appropriate radiotracers explores nondopaminergic neurotransmitter function, local metabolism, blood flow, and mechanisms potentially related to disease progression and pathogenesis. Activation studies using functional MRI detect blood oxygen level dependent signal, as an indirect marker of neuronal activity. Result: Functional imaging techniques have been applied to infer the potential role of inflammation and other factors in etiopathogenesis as well as to study compensatory and regulatory mechanisms in early PD and subclinical disease in genetic forms of PD. Imaging studies also help to understand the neurobiological basis of motor and nonmotor complications. Recent reports suggest a role for striatal dopaminergic transmission in modulating neurobehavioral processes including the placebo effect in PD. Although functional imaging has been employed to monitor disease progression, the discordance between clinical outcome and imaging measures after therapeutic interventions precludes their use as surrogate end points in clinical trials. Beyond these limitations and potential challenges, imaging techniques continue to find wide application in the study of PD. Conclusion: Functional imaging can provide meaningful insights into mechanisms underlying various aspects of motor and nonmotor dysfunction in Parkinson disease and the role of striatal dopaminergic transmission in behavioral processes beyond motor control. These modalities hold promise to study the preclinical phase and to elucidate further the benefits and complications of surgical interventions and the utility of neuroprotective strategies.
Affiliations:
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Mckeown</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Pacific Parkinson's Research Centre, University of British Columbia, Vancouver Hospital and Health Sciences Center</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Pacific Parkinson's Research Centre, University of British Columbia, Vancouver Hospital and Health Sciences Center</wicri:noRegion></affiliation></author><author><name sortKey="Stoessl, A Jon" sort="Stoessl, A Jon" uniqKey="Stoessl A" first="A. Jon" last="Stoessl">A. Jon Stoessl</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Pacific Parkinson's Research Centre, University of British Columbia, Vancouver Hospital and Health Sciences Center</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Pacific Parkinson's Research Centre, University of British Columbia, Vancouver Hospital and Health Sciences Center</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">08-0225249</idno><date when="2008">2008</date><idno type="stanalyst">PASCAL 08-0225249 INIST</idno><idno type="RBID">Pascal:08-0225249</idno><idno type="wicri:Area/PascalFrancis/Corpus">000651</idno><idno type="wicri:Area/PascalFrancis/Curation">000659</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000539</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000539</idno><idno type="wicri:doubleKey">0028-3878:2008:Nandhagopal R:invited:article:functional</idno><idno type="wicri:Area/Main/Merge">002600</idno><idno type="wicri:Area/Main/Curation">002397</idno><idno type="wicri:Area/Main/Exploration">002397</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Invited Article : Functional imaging in Parkinson disease</title><author><name sortKey="Nandhagopal, R" sort="Nandhagopal, R" uniqKey="Nandhagopal R" first="R." last="Nandhagopal">R. Nandhagopal</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Pacific Parkinson's Research Centre, University of British Columbia, Vancouver Hospital and Health Sciences Center</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Pacific Parkinson's Research Centre, University of British Columbia, Vancouver Hospital and Health Sciences Center</wicri:noRegion></affiliation></author><author><name sortKey="Mckeown, Martin J" sort="Mckeown, Martin J" uniqKey="Mckeown M" first="Martin J." last="Mckeown">Martin J. Mckeown</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Pacific Parkinson's Research Centre, University of British Columbia, Vancouver Hospital and Health Sciences Center</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Pacific Parkinson's Research Centre, University of British Columbia, Vancouver Hospital and Health Sciences Center</wicri:noRegion></affiliation></author><author><name sortKey="Stoessl, A Jon" sort="Stoessl, A Jon" uniqKey="Stoessl A" first="A. Jon" last="Stoessl">A. Jon Stoessl</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Pacific Parkinson's Research Centre, University of British Columbia, Vancouver Hospital and Health Sciences Center</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Pacific Parkinson's Research Centre, University of British Columbia, Vancouver Hospital and Health Sciences Center</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Functional imaging</term><term>Nervous system diseases</term><term>Parkinson disease</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Imagerie fonctionnelle</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective: Functional imaging techniques represent useful tools to assess in vivo the neurochemical alterations and functional connectivity in Parkinson disease (PD). Here, the authors review the various approaches and potential application of these imaging techniques to the study of PD. Method: Radiotracer imaging using dopaminergic markers facilitates assessment of pre- and postsynaptic nigrostriatal integrity, while imaging with other appropriate radiotracers explores nondopaminergic neurotransmitter function, local metabolism, blood flow, and mechanisms potentially related to disease progression and pathogenesis. Activation studies using functional MRI detect blood oxygen level dependent signal, as an indirect marker of neuronal activity. Result: Functional imaging techniques have been applied to infer the potential role of inflammation and other factors in etiopathogenesis as well as to study compensatory and regulatory mechanisms in early PD and subclinical disease in genetic forms of PD. Imaging studies also help to understand the neurobiological basis of motor and nonmotor complications. Recent reports suggest a role for striatal dopaminergic transmission in modulating neurobehavioral processes including the placebo effect in PD. Although functional imaging has been employed to monitor disease progression, the discordance between clinical outcome and imaging measures after therapeutic interventions precludes their use as surrogate end points in clinical trials. Beyond these limitations and potential challenges, imaging techniques continue to find wide application in the study of PD. Conclusion: Functional imaging can provide meaningful insights into mechanisms underlying various aspects of motor and nonmotor dysfunction in Parkinson disease and the role of striatal dopaminergic transmission in behavioral processes beyond motor control. These modalities hold promise to study the preclinical phase and to elucidate further the benefits and complications of surgical interventions and the utility of neuroprotective strategies.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Nandhagopal, R" sort="Nandhagopal, R" uniqKey="Nandhagopal R" first="R." last="Nandhagopal">R. Nandhagopal</name></noRegion><name sortKey="Mckeown, Martin J" sort="Mckeown, Martin J" uniqKey="Mckeown M" first="Martin J." last="Mckeown">Martin J. Mckeown</name><name sortKey="Stoessl, A Jon" sort="Stoessl, A Jon" uniqKey="Stoessl A" first="A. Jon" last="Stoessl">A. Jon Stoessl</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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